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Background: Triple-negative breast cancer (TNBC) is a subset of breast cancer. Health care cost and utilization data for TNBC are lacking.Objective: We examined differences between metastatic TNBC and metastatic non-TNBC in survival and health care costs and utilization.Methods: This retrospective... »
Community Translations
Regional nodal irradiation cuts breast cancer recurrence
Whole-breast irradiation (WBI) plus regional nodal irradiation (RNI) significantly improved disease-free survival, but not overall survival, in a randomized, multicenter phase III trial of women with node-positive or... »
Everolimus overcomes hormonal resistance in ER-positive breast cancer
A preplanned interim analysis of the phase III BOLERO- 2 trial in women with advanced hormone-resistant, estrogen receptor– positive (ER+) breast cancer showed that everolimus (Afinitor) combined with the aromatase... »
Exemestane for postmenopausal women at increased risk of breast cancer
Report prepared by Matt StengerThe selective estrogen-receptor modulators tamoxifen and raloxifene (Evista) are available for chemoprevention of breast cancer in women at increased risk of disease but are rarely used due to... »
Whole-breast irradiation (WBI) plus regional nodal irradiation (RNI) significantly improved disease-free survival, but not overall survival, in a randomized, multicenter phase III trial of women with node-positive or... »
Everolimus overcomes hormonal resistance in ER-positive breast cancer
A preplanned interim analysis of the phase III BOLERO- 2 trial in women with advanced hormone-resistant, estrogen receptor– positive (ER+) breast cancer showed that everolimus (Afinitor) combined with the aromatase... »
Exemestane for postmenopausal women at increased risk of breast cancer
Report prepared by Matt StengerThe selective estrogen-receptor modulators tamoxifen and raloxifene (Evista) are available for chemoprevention of breast cancer in women at increased risk of disease but are rarely used due to... »
Letters
Molecular tumor profile: another consideration for postmastectomy radiotherapy
I enjoyed the review article by Dr. Jeannie Shen (Community Oncology, December 2010), both for her succinct summary of the indications for postmastectomy plastic surgical reconstruction and the optimal timing of the... »
I enjoyed the review article by Dr. Jeannie Shen (Community Oncology, December 2010), both for her succinct summary of the indications for postmastectomy plastic surgical reconstruction and the optimal timing of the... »
Original Research
Retrospective study of patients with metastatic triple-negative breast cancer: survival, health care utilization, and cost
Background: Triple-negative breast cancer (TNBC) is a subset of breast cancer. Health care cost and utilization data for TNBC are lacking.Objective: We examined differences between metastatic TNBC and metastatic non-TNBC in... »
A Phase II Tolerability Trial of Neoadjuvant Docetaxel with Carboplatin and Capecitabine in Locally Advanced Breast Cancer
The standard of care for locally advanced breast cancer (LABC) is neoadjuvant chemotherapy,1 with LABC including clinical stages IIA, IIB, and IIIA. The goals of preoperative chemotherapy are to downstage so as to render... »
Background: Triple-negative breast cancer (TNBC) is a subset of breast cancer. Health care cost and utilization data for TNBC are lacking.Objective: We examined differences between metastatic TNBC and metastatic non-TNBC in... »
A Phase II Tolerability Trial of Neoadjuvant Docetaxel with Carboplatin and Capecitabine in Locally Advanced Breast Cancer
The standard of care for locally advanced breast cancer (LABC) is neoadjuvant chemotherapy,1 with LABC including clinical stages IIA, IIB, and IIIA. The goals of preoperative chemotherapy are to downstage so as to render... »
Reviews
Meeting Highlights From the 2011 Breast Cancer Symposium
The following reports are based on presentations at the 2011 Breast Cancer Symposium, held September 8–10 in San Francisco. The symposium was sponsored in part by the American Society of Clinical Oncology. Taxane-induced... »
Understanding the estrogen receptor signaling PATHWAY: focus on current endocrine agents for breast cancer in postmenopausal women
Adam M. Brufsky, MD, PhDUniversity of Pittsburgh School of Medicine, Pittsburgh, PAEstrogen receptor (ER) signaling plays a critical role in many breast cancers. As a result, endocrine therapy is a mainstay in the treatment... »
The following reports are based on presentations at the 2011 Breast Cancer Symposium, held September 8–10 in San Francisco. The symposium was sponsored in part by the American Society of Clinical Oncology. Taxane-induced... »
Understanding the estrogen receptor signaling PATHWAY: focus on current endocrine agents for breast cancer in postmenopausal women
Adam M. Brufsky, MD, PhDUniversity of Pittsburgh School of Medicine, Pittsburgh, PAEstrogen receptor (ER) signaling plays a critical role in many breast cancers. As a result, endocrine therapy is a mainstay in the treatment... »
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Community Oncology
Concentrates on original research,
rare cancers, quality of care in
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Highlights of the 6th Annual Community Oncology Conference. »
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