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Adverse Events Alert

Bevacizumab-associated diverticulitis

Counterfeit epoetin alfa products

Hematologic malignancy risk with granulocyte colony-stimulating factors

Inadvertent intrathecal administration of vincristine

Pharmacovigilance and reporting of bisphosphonate use and osteonecrosis of the jaw

Identifying and reporting adverse drug events in oncology

Thalidomide- and lenalidomide-associated thromboembolism

Brief Communications

Adenocarcinoma with choriocarcinoma and an endodermal sinus element in a patient with metastatic stomach cancer

A case of breast cancer detected by a pet dog

Recruiting more elderly patients for clinical trials

Dermatofibrosarcoma protuberans case report: when drug therapy can obviate the need for surgery

Detecting asymptomatic endometrial carcinoma by combined PET/CT

Complete remission of metastatic Ewing’s sarcoma/primitive neuroectodermal tumor with standard chemotherapy

Hypersensitivity reaction to carboplatin followed by reaction to cisplatin

Liposomal doxorubicin extravasation

Single cutaneous nodule as the first sign of lung cancer: a rare presentation

Mantle cell lymphoma of the prostate

Synchronous pancreatic cancer and mantle cell lymphoma: a case report

New paperless technology and HIPAA: medical policy at the crossroads

Strongyloidiasis diagnosed by endoscopic biopsy in a patient with multiple myeloma

Ultrasonography-guided assessment of surgical margins in oral carcinoma—a study of three cases

Palliation of vasomotor instability (“hot flashes”) using pregabalin

Cases in Community Oncology

A 68-year-old man with multiple colonic polyps discovered upon routine colonoscopy

Newly diagnosed metastatic gastric cancer

A 72-year-old man with a large, left-upper-lobe lung mass

Advances in the treatment of multiple myeloma

Challenging Cases/Rare Cancers

BRAIN TUMORS

Glioblastoma multiforme: advances in postsurgical management

BREAST CANCER

Breast cancer presenting in aberrant axillary breast tissue

Vulvar metastasis from breast cancer

CUTANEOUS MALIGNANCIES

Extramammary Paget’s disease

Merkel cell carcinoma: an uncommon and challenging disease entity

GYNECOLOGIC MALIGNANCIES

Evaluation and management of gestational trophoblastic disease

HEMATOLOGIC COMPLICATIONS

Endometrial adenocarcinoma with idiopathic thrombocytopenic purpura treated without chemotherapy or irradiation

Occurrence of immune thrombocytopenic purpura in patients with nonhematologic cancers

HEMATOLOGIC MALIGNANCIES

Intravascular B-cell lymphoma

Lymphoma with effusion in an HIV patient

The emerging role of novel therapeutic agents in the management of patients with multiple myeloma

LIVER CANCER

Liver-directed therapies for hepatocellular cancer

LUNG CANCER

Malignant mesothelioma

Paraneoplastic limbic encephalitis associated with small-cell lung cancer

NEUROENDOCRINE TUMORS

Adrenal hemorrhage associated with antiphospholipid antibody syndrome

Duodenal somatostatinoma and gastrointestinal stromal tumor associated with neurofibromatosis

Malignant paraganglioma

von Hippel-Lindau syndrome

OCCULT MALIGNANCIES

Occult systemic malignancy masquerading as thrombotic thrombocytopenic purpura–hemolytic uremic syndrome

PANCREATIC CANCER

Treatment update for metastatic pancreatic cancer

SARCOMAS

Cystosarcoma phyllodes with lymph node metastasis

The effects of ciprofloxacin and paclitaxel on metastatic and recurrent chondrosarcoma

THYROID CANCER

Differentiated thyroid cancer

TRANSPLANTATION

Treatment of a Jehovah's Witness using a transfusion-free autologous stem cell transplant protocol

Community Dialogue

K. Kian Ang, MD, PhD The head-and-neck cancer registry: a needed national database

Francis P. Arena, MD, FACP Clinical trials in community practice

Peter B. Bach, MD, MAPP Your open line to the CMS

Brian Baker The coming convergence of imaging and cancer treatment

Douglas W. Blayney, MD, and Barbara L. McAneny, MD Talking with the ASCO presidential candidates

Michael S. Buchholtz, MD, FACP Sizing up the competition

Barrie R. Cassileth, PhD Straight talk on alternative and complementary therapies

Atul Dhir, MBBS, DPhil Community oncology and cutting-edge research

David Eddy, MD, PhD Archimedes: oncology’s next top model?

Leslie Ford, MD Are Americans ready for cancer prevention in a pill?

Kathy Giusti Joining forces to beat multiple myeloma

Lawrence T. Goodnough, MD There will be blood: ESA restrictions, transfusions, and cancer patients

Clifford Hudis, MD, and Eric P. Winer, MD Can some ER-positive breast cancer patients forgo chemotherapy?

Elmer Huerta, MD, MPH Reaching the Latino community

Brian Klepper, PhD Facing the big-picture problem in healthcare

Silvana Martino, DO Fulfilling a duty to cancer patients

Mark McClellan, MD, PhD Overhauling Medicare: the big balancing act

William T. McGivney, PhD The NCCN guidelines: how do they relate to community oncology practice?

John E. Niederhuber, MD Bringing cancer care to people, where they live

Philip A. Pizzo, MD Championing transparency in clinical trials

Jerry Reeves, MD The new focus on accountability

Stephen H. Schneider, PhD The patient from hell

Philip Schulman, MD Satellite clinics: friend or foe?

Stephen F. Sener, MD Reflecting back, looking forward

Samuel Silver, MD, PhD New ESA guidelines from ASH-ASCO: the last word?

Robert E. Smith, Jr., MD, and Frank E. Sobash Coming together

Herman Suit, MD, PhD A radiation pioneer reflects

Jennifer T. Tam-McDevitt, PharmD, PhD, and Stuart Lichtman, MD Too many trials, not enough patients

Fiona Wilmot, MD, MPH Insurance coverage for rare cancers: the carrier’s perspective

Community Practice Profiles

Rocky Mountain Cancer Centers–Boulder

Community Translations

BREAST CANCER

Abraxane (nanoparticle albumin-bound paclitaxel) in metastatic breast cancer

Accelerated partial breast irradiation using MammoSite brachytherapy: a multidisciplinary approach to breast-conservation therapy

Aromatase inhibitors as adjuvant therapy for early-stage breast cancer

Dual HER1/HER2 inhibitor lapatinib in advanced/metastatic breast cancer

Ixabepilone in metastatic breast cancer

Predicting the outcome of breast cancer treatment by gene profiling

Long-term follow-up of a nonanthracycline regimen as adjuvant therapy for operable breast cancer

The STAR results: choosing between raloxifene and tamoxifen for preventing invasive breast cancer in postmenopausal women

Trastuzumab in adjuvant therapy for early-stage breast cancer

COLORECTAL CANCER

Bevacizumab: antiangiogenic success story

Bevacizumab in metastatic colorectal cancer and other settings

Capecitabine versus 5-FU in metastatic colorectal cancer: considerations for treatment decision-making

Chemotherapy of advanced colorectal cancer

Fluoropyrimidine therapy: a new chapter in an old story

GYNECOLOGICAL CANCERS

Intraperitoneal therapy for stage III optimally debulked ovarian cancer

HEAD AND NECK CANCER

Targeted therapy combined with radiotherapy for squamous cell head and neck cancer

HEMATOLOGICAL CANCERS

Azacitidine in myelodysplastic syndrome

Bendamustine in chronic lymphocytic leukemia

New BCR-ABL tyrosine kinase inhibitors for imatinib-resistant leukemias

Lenalidomide in myelodysplastic syndromes

Thalidomide in multiple myeloma

KIDNEY CANCER

Targeted therapy of renal cell carcinoma

Temsirolimus for advanced renal cell carcinoma

LIVER CANCER

Sorafenib in advanced hepatocellular carcinoma

LUNG CANCER

Activity of pemetrexed in thoracic malignancies

Erlotinib in non-small cell lung cancer

Platinum-based adjuvant therapy improves outcome in early NSCLC

PROSTATE CANCER

Chemotherapy for androgen-independent prostate cancer

Defining targets and protecting normal tissues in inverse-planned IMRT for prostate, head and neck, and gynecologic cancers: a comparative review

When PSA levels rise following surgery or radiation therapy

SKIN CANCER

Vorinostat in cutaneous T-cell lymphoma

SUPPORTIVE CARE

Developments in antiemetic therapy

Totect (dexrazoxane) for treatment of anthracycline extravasation

Deferasirox for chronic transfusional iron overload

Eculizumab for paroxysmal nocturnal hemoglobinuria

Calcium phosphate mouth rinse for preventing oral mucositis

Controversies in Patient Care

ADJUVANT THERAPY

Adjuvant therapy for colon cancer in the elderly: treat or don’t treat?

Aromatase inhibitors in adjuvant therapy: promise and uncertainty

Reducing the risk of recurrence in postmenopausal women with early breast cancer: a role for aromatase inhibitors

Update on fulvestrant for hormone receptor–positive advanced breast cancer

DIAGNOSIS AND STAGING

The role of MRI in breast imaging

Patients seeking second medical hematology/oncology opinions in the United States: a report of their demographics and disease processes

END-OF-LIFE ISSUES

Strategies for improving end-of-life care

Oncology and hospice care

GENETIC TESTING / RISK ASSESSMENT

Anticipating family issues associated with cancer risk assessment and genetic testing

Family history impacts patient care: how to recognize genetic risk

Genetic testing for hereditary melanoma: controversial, standard of care, or somewhere between the two?

Legal considerations in clinical cancer genetics

IMMUNOTHERAPY

Treatment options for the advanced asymptomatic prostate cancer patient: an active immunotherapy approach

PATIENT COUNSELING

Pregnancy after breast cancer

PHARMACOECONOMICS

Cancer-related anemia: when dollars and cents—not science—dictate treatment

Erythropoiesis-stimulating agents: whatever happened to evidence-based medicine?

Is oncology compatible with specialty pharmacy?

Medicare’s drug plan: huge price disparities for common cancer drugs

Prophylactic mastectomy and the clinical management of high-risk breast cancer patients

PROGNOSIS

Circulating tumor cells in the management of metastatic breast cancer patients

RADIATION THERAPY

Radiation therapy for cutaneous melanoma: 2008 update

SURGICAL MANAGEMENT

The evolving role of laparoscopy in the surgical management of oncology patients

Current Clinical Trials

Assessing the combination of FOLFOX or FOLFIRI with bevacizumab, cetuximab, or both in metastatic colorectal cancer

Carbohydrate restriction in patients with advanced cancer: a protocol to assess safety and feasibility with an accompanying hypothesis

The TAILORx trial: individualized options for treatment

Economics/Practice Management

Cancer in America, 2004

Will partial breast irradiation be a cost-effective alternative to whole breast irradiation in the treatment of early-stage breast cancer?

Discover the genius within your organization: the benefits of personality assessment tools

The smart medical oncology partnership

NOA treatment guidelines: interactive clinical and business support for the 21st century oncology office

Preventing chemotherapy-induced nausea and vomiting: the economic implications of choosing antiemetics

Making the transition to digital mammography

The new language of cancer care: contribution to working capital, human resource costs, practice efficiency, and opportunity costs

Spotting the time bombs in your managed care contracts

Maximizing your profits with pharmacy control strategies

Efficient practice management: a nine-point action plan

Is your practice ready for an uncertain future? The questions you should be asking your staff

Hospitalizations subsequent to the diagnosis of lung cancer: a clinical and financial analysis

Board-certified oncology pharmacists: partners in the multidisciplinary care of cancer patients

Developing and operating multidisciplinary disease-specific clinics

Emergency preparedness for cancer clinics—a necessity

Savvy purchasing

A dispensing pharmacy: is it right for your community practice?

Nine ways to improve efficiency in an ambulatory infusion center

Financial benchmarking: results from a survey of office-based oncology practices

EMR update

Creating a culture of customer service

Practice–hospital partnerships: a marriage made for patients

Implementing Clinical Trials

Poor access to clinical trials among newly diagnosed adult cancer patients in the community—1999–2004

The clinical network: a different approach

The benefits and challenges of conducting clinical trials

Managing drug accountability

Recruiting and enrolling minority patients to cancer clinical trials

Community participation in NCI-sponsored clinical trials

Healthcare and clinical research: a critical link through standards

Managing Side Effects

Epoetin alfa for chemotherapy-induced anemia: assessment of two equivalent dosing regimens

Managing and avoiding bortezomib toxicity

Managing medical complications in patients with brain tumors

Chemotherapeutics and cardiac toxicity: treatment considerations and management strategies

Trastuzumab and cardiac toxicity: monitoring in the adjuvant setting

Managing cutaneous side effects of epidermal growth factor receptor (HER1/EGFR) inhibitors

Depression in the patient with brain cancer

Management of febrile neutropenia

Hypertension therapy for the oncology patient

Clinical evaluation and treatment of insomnia in patients with cancer

Iron or vitamin B12 deficiency in anemic cancer patients prior to erythropoiesis-stimulating agent therapy

Managing lymphedema, a lingering problem for breast cancer patients

Osteonecrosis of the jaw associated with bisphosphonate therapy: tips for the practicing oncologist

Pegfilgrastim-induced bone pain: incidence, risk factors, and management in a community practice

Recognizing and treating a new entity on the quality-of-life front: small intestinal bacterial overgrowth

Prevention and treatment of vaginal stenosis resulting from pelvic radiation therapy

Low-molecular-weight heparins in the prevention and management of malignancy-related venous thromboembolism

Medical Management

Helping breast cancer patients adhere to oral adjuvant hormonal therapy regimens

Nursing Management

Safeguarding patients and avoiding medical errors in chemotherapy infusion suites

Implementing a multisymptom chemotherapy risk assessment tool in two community oncology practices

Educational and emotional support of patients with non-Hodgkin’s lymphoma

Managing follicular rash related to chemotherapy and monoclonal antibodies

Managing mucositis in head and neck cancer patients undergoing radiation therapy

Managing the side effects of sorafenib and sunitinib

Telephone contacts between triage nurses and cancer patients

Original Contributions

BREAST CANCER

Evaluating adjuvant hormonal therapy in early-stage breast cancer: a comparison of predictive decision models

Partial breast irradiation: a community hospital approach in community practice

Implementation of sentinel node biopsy for breast cancer in a community hospital

BRAIN TUMORS

Radiosurgical treatment of brain metastases in a community oncologic practice in community practice

COLORECTAL CANCER

Gaps in colorectal cancer outcomes research

ESOPHAGEAL CANCER

Concurrent chemoradiation followed by esophageal resection vs chemoradiation alone for localized esophageal cancer

GYNECOLOGIC MALIGNANCIES

Early treatment with rhIL-11 in heavily pretreated patients with gynecologic cancer

Toxicity of intraperitoneal chemotherapy may be related to age in women treated for optimally debulked ovarian cancer

Update on minimally invasive surgery in the management of gynecologic malignancies: focus on robotic laparoscopic systems

HEAD AND NECK CANCER

Selected topics in head and neck cancer

HEMATOLOGICAL MALIGNANCIES

Novel agents for chronic myeloid leukemia: from imatinib to dasatinib and nilotinib

Chronic low dose-intensity pegylated liposomal doxorubicin for advanced malignancies

Lymphoid malignancies: a previously unrecognized risk factor for bone loss

Primary mediastinal large B-cell lymphoma: a retrospective analysis of rituximab and CHOP chemotherapy

Importance of molecular confirmation in the diagnosis of myeloproliferative disorders

LIVER CANCER

Emerging therapies for metastatic carcinoma to the liver

PROSTATE CANCER

Brachytherapy for prostate cancer

Conformal proton beam radiation therapy for prostate cancer: concepts and clinical results

IMRT for prostate cancer: improving the therapeutic ratio

The role of radiotherapy in the treatment of locally advanced prostate cancer

RADIOTHERAPY

Proton beam radiotherapy: a specialized treatment alternative

Spinal radiosurgery for metastatic disease

Stereotactic body radiation therapy: 2007 update

SARCOMAS

Chronic low dose-intensity pegylated liposomal doxorubicin for advanced malignancies

Genetic approaches to sarcoma diagnosis

SOLID TUMORS

Chronic low dose-intensity pegylated liposomal doxorubicin for advanced malignancies

SUPPORTIVE CARE

Bevacizumab-related toxicities: association of hypertension and proteinuria

Costs of human resources in delivering cancer chemotherapy and managing chemotherapy-induced neutropenia in community practice

The impact of first and subsequent cycle pegfilgrastim on neutropenic events in patients receiving myelosuppressive chemotherapy in community practice: interim results of the prospective FIRST study

The impact of medical visits for chemotherapy-induced anemia and neutropenia on the patient and caregiver: a national survey

Uncompensated costs associated with the outpatient management of cancer chemotherapy–associated febrile neutropenia

Pharmacogenetics

Irinotecan pharmacogenetics: an overview for the community oncologist

Practice Survival

Dealing with the difficult patient

The baptism

Caring in five minutes

Utilizing oncology nurse practitioners: a model strategy

Unmet expectations

Where faith and medicine meet

Psychosocial Oncology

Breaking bad news: the S-P-I-K-E-S strategy

Effect of oncologist-based counseling on patient-perceived breast cancer risk and psychological distress

Initiating a community-based cancer supportive care program

Caring for the whole patient: the Institute of Medicine proposes a new standard of care

Modesty and healthcare for women: understanding cultural sensitivities

Recognizing depression in cancer outpatients

Emotional distress in patients with cancer: the sixth vital sign

End of treatment—laugh or cry?

Patients’ and families’ receptivity to discussions about future healthcare

The explosion of hereditary cancer knowledge: benefiting from a family information service

Putting shared decision making to work in breast and prostate cancers: tools for community oncologists

Developing and implementing a survivorship program in a community cancer center

Quality Care

Better margins, better quality: seizing the moment

Implementing evidence-based guidelines for preventing chemotherapy-induced neutropenia: from paper to clinical practice

Treating elderly cancer patients: what you need to know about their physiology and specific medical needs

Customizing EMR clickables

Better communication with minority patients: seven strategies for achieving cultural competency

Opinion leaders on quality in cancer: views from the field

A call for action: leadership is needed now on quality, safety, and pay for performance in community oncology

PQRI: should you take part?

Quality measurement in oncology practices

Review Articles

AIDS-related cancers, part I: Kaposi’s sarcoma and cervical cancer

AIDS-related cancers, part II: Systemic and cerebral lymphomas

Image-guided radiation therapy: techniques and strategies

Management of metastatic colorectal cancer: the impact of clinical trials reported at ASCO 2007

The adverse health effects of occupational exposure to hazardous drugs

Developing a hazardous drug safe-handling program

Technology

AnalyzeIt—software that provides the true costs of regimens and services by CPT codes

Cancer information on the Internet: the impact of employing specific search engines and search strategies

CME in cyberspace

Data mining for quality care

Electronic medical records: taking the plunge

Results of our EMR survey: what readers told us

In the loop: building your own Intranet

You’ve got mail

Take a meeting—in cyberspace

One-click prescribing

Picking the right PDA

PDA applications: drug reference guides

Top 10 PDA programs for oncology practices

The pocket-sized billing department

Feeding your software-hungry PDA

Podcasting: your information pipeline

Synchronized swimming: coordinating schedules and calendars with your colleagues

I hear a voice: using speech-recognition systems in community practice

Tablet PCs: getting to the heart of the matter

How 'tech toys' have helped one doctor run a more efficient practice

Web site review: staying UpToDate